InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: COL4A3BP

Summary

InnateDB Protein

IDBP-294200.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COL4A3BP

Protein Name

collagen, type IV, alpha 3 (Goodpasture antigen) binding protein

Synonyms

CERT; CERTL; GPBP; STARD11;

Species

Homo sapiens

Ensembl Protein

ENSP00000383996

InnateDB Gene

IDBG-29012 (COL4A3BP)

Protein Structure

UniProt Annotation

Function

Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. {ECO:0000269PubMed:14685229, ECO:0000269PubMed:17591919, ECO:0000269PubMed:18184806, ECO:0000269PubMed:20036255}.

Subcellular Localization

Cytoplasm. Golgi apparatus. Endoplasmic reticulum. Note=Preferentially localized to the Golgi apparatus.

Disease Associations

Tissue Specificity

Widely expressed.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0008289	lipid binding
GO:0035620	ceramide transporter activity
GO:0070273	phosphatidylinositol-4-phosphate binding
GO:0097001	ceramide binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006665	sphingolipid metabolic process
GO:0006955	immune response
GO:0030148	sphingolipid biosynthetic process
GO:0035621	ER to Golgi ceramide transport
GO:0044281	small molecule metabolic process