Version 5.4
Homo sapiens Gene: COL4A3BP
Summary
InnateDB Gene IDBG-29012.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COL4A3BP
Gene Name collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
Synonyms CERT; CERTL; GPBP; STARD11
Species Homo sapiens
Ensembl Gene ENSG00000113163
Encoded Proteins
IDBP-29014
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
IDBP-29020
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
IDBP-29022
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
IDBP-294200
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
IDBP-475008
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:75368486-75512138
Strand Reverse strand
Band q13.3
Transcripts
ENST00000380494 ENSP00000369862
ENST00000261415 ENSP00000261415
ENST00000357457 ENSP00000350046
ENST00000405807 ENSP00000383996
ENST00000508692
ENST00000508809 ENSP00000424244
ENST00000604926
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0016301 kinase activity
GO:0035620 ceramide transporter activity
GO:0070273 phosphatidylinositol-4-phosphate binding
GO:0097001 ceramide binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001701 in utero embryonic development
GO:0003007 heart morphogenesis
GO:0006468 protein phosphorylation
GO:0006665 sphingolipid metabolic process
GO:0006672 ceramide metabolic process
GO:0006936 muscle contraction
GO:0006955 immune response
GO:0007029 endoplasmic reticulum organization
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0016310 phosphorylation
GO:0030148 sphingolipid biosynthetic process
GO:0034976 response to endoplasmic reticulum stress
GO:0035621 ER to Golgi ceramide transport
GO:0044281 small molecule metabolic process
GO:0055088 lipid homeostasis
GO:0070584 mitochondrion morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021669
View Gene Order
ENSBTAG00000000081
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001130105 NM_005713 NM_031361 XM_006714513
HUGO
OMIM
CCDS CCDS4028 CCDS4029 CCDS47235
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca