InnateDB Protein
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IDBP-294282.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ELAVL1
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Protein Name
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ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
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Synonyms
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ELAV1; Hua; HUR; MelG;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000385269
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InnateDB Gene
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IDBG-24117 (ELAVL1)
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Protein Structure
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Function |
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU- rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA. {ECO:0000269PubMed:19029303}.
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Subcellular Localization |
Cytoplasm. Nucleus. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2.
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Disease Associations |
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 622 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
15 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
IPR002343
Paraneoplastic encephalomyelitis antigen
IPR006548
Splicing factor ELAV/HuD
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PFAM |
PF00076
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PRINTS |
PR00961
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q15717
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PhosphoSite |
PhosphoSite-Q15717
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TrEMBL |
B4DVB8
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UniProt Splice Variant |
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Entrez Gene |
1994
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UniGene |
Hs.713744
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RefSeq |
NP_001410
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HUGO |
HGNC:3312
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OMIM |
603466
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CCDS |
CCDS12193
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HPRD |
16025
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IMGT |
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EMBL |
AC008975
AC010336
AK301013
BC003376
BT009793
CH471139
U38175
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GenPept |
AAB41913
AAH03376
AAP88795
BAG62630
EAW68949
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