Version 5.4
Homo sapiens Protein: SMPD4
Summary
InnateDB Protein IDBP-294287.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMPD4
Protein Name sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000386531
InnateDB Gene IDBG-69645 (SMPD4)
Protein Structure
UniProt Annotation
Function Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. {ECO:0000269PubMed:16517606}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:16517606}; Single-pass membrane protein {ECO:0000269PubMed:16517606}. Golgi apparatus membrane {ECO:0000269PubMed:16517606}; Single-pass membrane protein {ECO:0000269PubMed:16517606}.
Disease Associations
Tissue Specificity Widely expressed, with highest levels in heart and skeletal muscle. {ECO:0000269PubMed:16517606}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004767 sphingomyelin phosphodiesterase activity
GO:0046872 metal ion binding
GO:0050290 sphingomyelin phosphodiesterase D activity
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006685 sphingomyelin catabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0008152 metabolic process
GO:0044281 small molecule metabolic process
GO:0046475 glycerophospholipid catabolic process
GO:0046513 ceramide biosynthetic process
GO:0071356 cellular response to tumor necrosis factor
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q9NXE4
TrEMBL C9J647
UniProt Splice Variant
Entrez Gene 55627
UniGene Hs.739107
RefSeq NP_060421
HUGO HGNC:32949
OMIM 610457
CCDS CCDS42751
HPRD 13374
IMGT
EMBL AB037839 AC018804 AK000304 AK000763 AK001227 AK126920 AK297257 AK298609 AK299185 AK301576 AK303427 AL136737 BC064947 CH471263 CR533550 EU367941
GenPept AAH64947 AAY14883 ACA48221 BAA91070 BAA91368 BAA91567 BAA92656 BAC86751 BAG59735 BAG60793 BAG61230 BAG63069 BAG64478 CAB66671 CAG38581 EAW55600

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca