Version 5.4
Homo sapiens Gene: SMPD4
Summary
InnateDB Gene IDBG-69645.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMPD4
Gene Name sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000136699
Encoded Proteins
IDBP-69647
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
IDBP-294287
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
IDBP-385871
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
IDBP-385876
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
IDBP-385877
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
IDBP-385885
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
IDBP-385887
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
IDBP-385889
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
IDBP-385890
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
IDBP-385891
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
IDBP-385892
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
IDBP-385893
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
IDBP-385894
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
IDBP-385895
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Sphingomyelinases (EC 3.1.4.12), such as SMPD4, catalyze the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (Krut et al., 2006 [PubMed 16517606]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:130151392-130182750
Strand Reverse strand
Band q21.1
Transcripts
ENST00000351288 ENSP00000259217
ENST00000409031 ENSP00000386531
ENST00000433118 ENSP00000397278
ENST00000412570 ENSP00000403002
ENST00000454468 ENSP00000407591
ENST00000431183 ENSP00000405187
ENST00000439886 ENSP00000401648
ENST00000457039 ENSP00000397078
ENST00000449159 ENSP00000403915
ENST00000430682 ENSP00000406325
ENST00000435455 ENSP00000393791
ENST00000451542 ENSP00000405363
ENST00000439029 ENSP00000416208
ENST00000441135 ENSP00000406458
ENST00000455548
ENST00000491319
ENST00000491128
ENST00000482171
ENST00000461187
ENST00000473720
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004767 sphingomyelin phosphodiesterase activity
GO:0046872 metal ion binding
GO:0050290 sphingomyelin phosphodiesterase D activity
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006685 sphingomyelin catabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0008152 metabolic process
GO:0044281 small molecule metabolic process
GO:0046475 glycerophospholipid catabolic process
GO:0046513 ceramide biosynthetic process
GO:0071356 cellular response to tumor necrosis factor
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005899
View Gene Order
ENSBTAG00000002130
Not yet available
Pathways
NETPATH
REACTOME
REACT_116105
Glycosphingolipid metabolism pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.516450 Hs.739107
RefSeq NM_001171083 NM_017751 NM_017951 XM_005263704 XM_006712625
HUGO
OMIM
CCDS CCDS2156 CCDS42751 CCDS54398
HPRD 13374
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca