Homo sapiens Protein: IRF5 | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||||||
InnateDB Protein | IDBP-294353.5 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | IRF5 | ||||||||||||||||||||||||||
Protein Name | interferon regulatory factor 5 | ||||||||||||||||||||||||||
Synonyms | SLEB10; | ||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||
Ensembl Protein | ENSP00000385352 | ||||||||||||||||||||||||||
InnateDB Gene | IDBG-40393 (IRF5) | ||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||
Function | Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. {ECO:0000269PubMed:11303025, ECO:0000269PubMed:15695821}. | ||||||||||||||||||||||||||
Subcellular Localization | Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm. | ||||||||||||||||||||||||||
Disease Associations | Inflammatory bowel disease 14 (IBD14) [MIM:612245]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269PubMed:17881657}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Systemic lupus erythematosus 10 (SLEB10) [MIM:612251]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269PubMed:15657875}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269PubMed:17599733}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. | ||||||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 74 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||||||
Protein Structure and Domains | |||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||
InterPro |
IPR001346
Interferon regulatory factor DNA-binding domain IPR008984 SMAD/FHA domain IPR019471 Interferon regulatory factor-3 |
||||||||||||||||||||||||||
PFAM |
PF00605
PF10401 |
||||||||||||||||||||||||||
PRINTS |
PR00267
|
||||||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||||||
SMART |
SM00348
|
||||||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | Q13568 | ||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q13568 | ||||||||||||||||||||||||||
TrEMBL | Q64GB0 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 3663 | ||||||||||||||||||||||||||
UniGene | Hs.614535 | ||||||||||||||||||||||||||
RefSeq | NP_001092100 | ||||||||||||||||||||||||||
HUGO | HGNC:6120 | ||||||||||||||||||||||||||
OMIM | 607218 | ||||||||||||||||||||||||||
CCDS | CCDS5808 | ||||||||||||||||||||||||||
HPRD | 06240 | ||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | AC025594 AY504946 AY504947 AY693665 AY693666 AY693667 AY693668 BC004139 BC004201 CH236950 CH471070 DQ277633 DQ277634 DQ995495 DQ995496 EF064718 JQ950681 U51127 | ||||||||||||||||||||||||||
GenPept | AAA96056 AAH04139 AAH04201 AAR90325 AAR90326 AAU12877 AAU12878 AAU12879 AAU12880 ABB88960 ABB88961 ABK41901 ABL96293 ABL96294 AFN70752 EAL24107 EAL24108 EAW83703 EAW83704 EAW83705 EAW83707 | ||||||||||||||||||||||||||