InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: INPP5J

Summary

InnateDB Protein

IDBP-294412.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INPP5J

Protein Name

inositol polyphosphate-5-phosphatase J

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384596

InnateDB Gene

IDBG-4479 (INPP5J)

Protein Structure

UniProt Annotation

Function

Inositol 5-phosphatase, which converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4- phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate- binding proteins that are present at membranes ruffles (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=Predominantly localized to membrane ruffles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004445	inositol-polyphosphate 5-phosphatase activity
GO:0017124	SH3 domain binding
GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0046856	phosphatidylinositol dephosphorylation