InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADCYAP1R1

Summary

InnateDB Protein

IDBP-294438.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADCYAP1R1

Protein Name

adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

Synonyms

PAC1; PAC1R; PACAPR; PACAPRI;

Species

Homo sapiens

Ensembl Protein

ENSP00000387335

InnateDB Gene

IDBG-11429 (ADCYAP1R1)

Protein Structure

UniProt Annotation

Function

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004999	vasoactive intestinal polypeptide receptor activity
GO:0005515	protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007283	spermatogenesis
GO:0030154	cell differentiation
GO:0048011	neurotrophin TRK receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000832 GPCR, family 2, secretin-like
IPR001771 GPCR, family 2, vasoactive intestinal peptide receptor 1
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR002284 GPCR, family 2, vasoactive intestinal peptide receptor 2
IPR002285 GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor
IPR017981 GPCR, family 2-like

PFAM

PF00002
PF02793

PRINTS

PR00249
PR01154
PR01155
PR01156

PIRSF

SMART

SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt