InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GAL3ST1

Summary

InnateDB Protein

IDBP-294509.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAL3ST1

Protein Name

galactose-3-O-sulfotransferase 1

Synonyms

CST;

Species

Homo sapiens

Ensembl Protein

ENSP00000385735

InnateDB Gene

IDBG-4240 (GAL3ST1)

Protein Structure

UniProt Annotation

Function

Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro). {ECO:0000250, ECO:0000269PubMed:8830034}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in kidney proximal tubule, gastric mucosa and adenocarcinoma. Highly expressed in renal cell carcinoma cell lines.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001733	galactosylceramide sulfotransferase activity
GO:0008146	sulfotransferase activity

Biological Process

GO:0006487	protein N-linked glycosylation
GO:0006665	sphingolipid metabolic process
GO:0006682	galactosylceramide biosynthetic process
GO:0006687	glycosphingolipid metabolic process
GO:0007283	spermatogenesis
GO:0009058	biosynthetic process
GO:0042552	myelination
GO:0044281	small molecule metabolic process

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane