Version 5.4
Homo sapiens Gene: GAL3ST1
Summary
InnateDB Gene IDBG-4240.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GAL3ST1
Gene Name galactose-3-O-sulfotransferase 1
Synonyms CST
Species Homo sapiens
Ensembl Gene ENSG00000128242
Encoded Proteins
IDBP-4242
galactose-3-O-sulfotransferase 1
IDBP-294509
galactose-3-O-sulfotransferase 1
IDBP-294508
galactose-3-O-sulfotransferase 1
IDBP-294523
galactose-3-O-sulfotransferase 1
IDBP-294507
galactose-3-O-sulfotransferase 1
IDBP-294516
galactose-3-O-sulfotransferase 1
IDBP-371981
galactose-3-O-sulfotransferase 1
IDBP-371984
galactose-3-O-sulfotransferase 1
IDBP-371986
galactose-3-O-sulfotransferase 1
IDBP-371988
galactose-3-O-sulfotransferase 1
IDBP-371991
galactose-3-O-sulfotransferase 1
IDBP-371992
galactose-3-O-sulfotransferase 1
IDBP-371994
galactose-3-O-sulfotransferase 1
IDBP-371997
galactose-3-O-sulfotransferase 1
IDBP-371998
galactose-3-O-sulfotransferase 1
IDBP-372002
galactose-3-O-sulfotransferase 1
IDBP-372004
galactose-3-O-sulfotransferase 1
IDBP-372005
galactose-3-O-sulfotransferase 1
IDBP-372008
galactose-3-O-sulfotransferase 1
IDBP-372010
galactose-3-O-sulfotransferase 1
IDBP-372011
galactose-3-O-sulfotransferase 1
IDBP-372012
galactose-3-O-sulfotransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3',5'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma. [provided by RefSeq, Jul 2008]
Sulfonation, an important step in the metabolism of many drugs, xenobiotics, hormones, and neurotransmitters, is catalyzed by sulfotransferases. The product of this gene is galactosylceramide sulfotransferase which catalyzes the conversion between 3\'-phosphoadenylylsulfate + a galactosylceramide to adenosine 3\',5\'-bisphosphate + galactosylceramide sulfate. Activity of this sulfotransferase is enhanced in renal cell carcinoma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:30554635-30574587
Strand Reverse strand
Band q12.2
Transcripts
ENST00000338911 ENSP00000343234
ENST00000402321 ENSP00000385735
ENST00000402369 ENSP00000384122
ENST00000406955 ENSP00000385825
ENST00000401975 ENSP00000384388
ENST00000406361 ENSP00000385207
ENST00000441967 ENSP00000390545
ENST00000431313 ENSP00000395080
ENST00000452827 ENSP00000405017
ENST00000437282 ENSP00000401426
ENST00000416358 ENSP00000391485
ENST00000427899 ENSP00000397092
ENST00000423299 ENSP00000391996
ENST00000443136 ENSP00000405381
ENST00000423371 ENSP00000401074
ENST00000428682 ENSP00000389876
ENST00000453479 ENSP00000398380
ENST00000426220 ENSP00000414542
ENST00000447224 ENSP00000412995
ENST00000411821 ENSP00000394912
ENST00000445645 ENSP00000399649
ENST00000448604 ENSP00000390068
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001733 galactosylceramide sulfotransferase activity
GO:0008146 sulfotransferase activity
Biological Process
GO:0006487 protein N-linked glycosylation
GO:0006665 sphingolipid metabolic process
GO:0006682 galactosylceramide biosynthetic process
GO:0006687 glycosphingolipid metabolic process
GO:0007283 spermatogenesis
GO:0009058 biosynthetic process
GO:0042552 myelination
GO:0044281 small molecule metabolic process
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049721
View Gene Order
ENSBTAG00000014232
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00600
Sphingolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.17958 Hs.605267
RefSeq NM_004861 XM_005261848 XM_005261853 XM_005261856
HUGO
OMIM
CCDS CCDS13879
HPRD 03806
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca