InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEC14L2

Summary

InnateDB Protein

IDBP-294550.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEC14L2

Protein Name

SEC14-like 2 (S. cerevisiae)

Synonyms

C22orf6; SPF; TAP; TAP1;

Species

Homo sapiens

Ensembl Protein

ENSP00000385186

InnateDB Gene

IDBG-4120 (SEC14L2)

Protein Structure

UniProt Annotation

Function

Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.

Subcellular Localization

Cytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha- tocopherol.

Disease Associations

Tissue Specificity

Widely expressed. Strong expression in liver, brain and prostate. {ECO:0000269PubMed:10829015}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005543	phospholipid binding
GO:0008431	vitamin E binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006810	transport
GO:0045540	regulation of cholesterol biosynthetic process
GO:0045893	positive regulation of transcription, DNA-templated