Version 5.4
Homo sapiens Gene: SEC14L2
Summary
InnateDB Gene IDBG-4120.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEC14L2
Gene Name SEC14-like 2 (S. cerevisiae)
Synonyms C22orf6; SPF; TAP; TAP1
Species Homo sapiens
Ensembl Gene ENSG00000100003
Encoded Proteins
IDBP-294550
SEC14-like 2 (S. cerevisiae)
IDBP-294546
SEC14-like 2 (S. cerevisiae)
IDBP-371812
SEC14-like 2 (S. cerevisiae)
IDBP-371826
SEC14-like 2 (S. cerevisiae)
IDBP-371830
SEC14-like 2 (S. cerevisiae)
IDBP-371835
SEC14-like 2 (S. cerevisiae)
IDBP-371839
SEC14-like 2 (S. cerevisiae)
IDBP-807626
SEC14-like 2 (S. cerevisiae)
IDBP-807629
SEC14-like 2 (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream enzyme in the cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:30396857-30425317
Strand Forward strand
Band q12.2
Transcripts
ENST00000405717 ENSP00000385186
ENST00000402592 ENSP00000383882
ENST00000428195 ENSP00000387781
ENST00000452649 ENSP00000388888
ENST00000437022 ENSP00000388719
ENST00000416523
ENST00000429917 ENSP00000407857
ENST00000415072 ENSP00000399596
ENST00000459728
ENST00000485482
ENST00000464335
ENST00000484486
ENST00000483116
ENST00000615189 ENSP00000478755
ENST00000617837 ENSP00000482467
ENST00000619483
ENST00000620251
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005543 phospholipid binding
GO:0008431 vitamin E binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006810 transport
GO:0045540 regulation of cholesterol biosynthetic process
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003585
View Gene Order
ENSBTAG00000017404
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt
TrEMBL B3KRD8
UniProt Splice Variant
Entrez Gene 23541
UniGene
RefSeq NM_001204204 NM_001291932 NM_012429 NM_033382
HUGO HGNC:10699
OMIM 607558
CCDS CCDS13876 CCDS46685 CCDS56228
HPRD
IMGT
EMBL AC004832 AK091402 CH471095
GenPept BAG52350 EAW59887
RNA Seq Atlas 23541

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca