InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNAJA2

Summary

InnateDB Protein

IDBP-29460.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAJA2

Protein Name

DnaJ (Hsp40) homolog, subfamily A, member 2

Synonyms

CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4; PRO3015; RDJ2;

Species

Homo sapiens

Ensembl Protein

ENSP00000314030

InnateDB Gene

IDBG-29458 (DNAJA2)

Protein Structure

UniProt Annotation

Function

Co-chaperone of Hsc70.

Subcellular Localization

Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	52 [view]
Protein-Protein	51 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0031072	heat shock protein binding
GO:0046872	metal ion binding
GO:0051082	unfolded protein binding
GO:0051087	chaperone binding

Biological Process

GO:0006457	protein folding
GO:0008284	positive regulation of cell proliferation
GO:0009408	response to heat
GO:0042026	protein refolding

Cellular Component

GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001305 Heat shock protein DnaJ, cysteine-rich domain
IPR001623 DnaJ domain
IPR002939 Chaperone DnaJ, C-terminal
IPR008971 HSP40/DnaJ peptide-binding

PFAM

PF00684
PF00226
PF01556

PRINTS

PR00625

PIRSF

SMART

SM00271

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt