Version 5.4
Homo sapiens Gene: DNAJA2
Summary
InnateDB Gene IDBG-29458.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAJA2
Gene Name DnaJ (Hsp40) homolog, subfamily A, member 2
Synonyms CPR3; DJ3; DJA2; DNAJ; DNJ3; HIRIP4; PRO3015; RDJ2
Species Homo sapiens
Ensembl Gene ENSG00000069345
Encoded Proteins
IDBP-29460
DnaJ (Hsp40) homolog, subfamily A, member 2
IDBP-748565
IDBP-810474
DnaJ (Hsp40) homolog, subfamily A, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:46955362-46973788
Strand Reverse strand
Band q11.2
Transcripts
ENST00000317089 ENSP00000314030
ENST00000563158 ENSP00000460104
ENST00000569553
ENST00000617000 ENSP00000477579
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 51 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0031072 heat shock protein binding
GO:0046872 metal ion binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
Biological Process
GO:0006457 protein folding
GO:0008284 positive regulation of cell proliferation
GO:0009408 response to heat
GO:0042026 protein refolding
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031701
View Gene Order
ENSBTAG00000003757
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt O60884
TrEMBL A0A024R6S1 H3BMW5 I3L320
UniProt Splice Variant
Entrez Gene 10294
UniGene Hs.368078 Hs.595856 Hs.701074 Hs.703099
RefSeq NM_005880
HUGO HGNC:14884
OMIM 611322
CCDS CCDS10726
HPRD
IMGT
EMBL AC018845 AF011793 AJ001309 AK313031 BC013044 BC015809 CH471092 Y13350
GenPept AAB69313 AAH13044 AAH15809 BAG35864 CAA04669 CAA73791 EAW82693 EAW82694
RNA Seq Atlas 10294

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca