Version 5.4
| Homo sapiens Protein: MEX3C | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Protein | IDBP-294664.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | MEX3C | ||||||||||||||||||
| Protein Name | mex-3 homolog C (C. elegans) | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Protein | ENSP00000385610 | ||||||||||||||||||
| InnateDB Gene | IDBG-3505 (MEX3C) | ||||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||||
| Function | E3 ubiquitin ligase responsible for the post- transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269PubMed:22863774, ECO:0000269PubMed:23446422}. | ||||||||||||||||||
| Subcellular Localization | Cytoplasm {ECO:0000269PubMed:17267406}. Nucleus {ECO:0000269PubMed:17267406}. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation. | ||||||||||||||||||
| Disease Associations | Note=Genetic variations in MEX3C may be associated with susceptibility to essential hypertension. | ||||||||||||||||||
| Tissue Specificity | Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine. {ECO:0000269PubMed:17267406, ECO:0000269PubMed:22863774}. | ||||||||||||||||||
| Comments | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||||
| PDB ID | |||||||||||||||||||
| InterPro |
IPR001841
Zinc finger, RING-type IPR004087 K Homology domain IPR004088 K Homology domain, type 1 |
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| PFAM |
PF13639
PF14634 PF00013 PF13014 |
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| PRINTS | |||||||||||||||||||
| PIRSF | |||||||||||||||||||
| SMART |
SM00184
SM00322 |
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| TIGRFAMs | |||||||||||||||||||
| Post-translational Modifications | |||||||||||||||||||
| Modification | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q5U5Q3 | ||||||||||||||||||
| PhosphoSite | PhosphoSite-Q5U5Q3 | ||||||||||||||||||
| TrEMBL | B3KTW5 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 51320 | ||||||||||||||||||
| UniGene | Hs.678764 | ||||||||||||||||||
| RefSeq | NP_057710 | ||||||||||||||||||
| HUGO | HGNC:28040 | ||||||||||||||||||
| OMIM | 611005 | ||||||||||||||||||
| CCDS | CCDS11951 | ||||||||||||||||||
| HPRD | 15255 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC090330 AF208855 AK096190 AK312049 AY950679 BC041122 KC456343 | ||||||||||||||||||
| GenPept | AAF64269 AAH41122 AAY34147 AGI99528 BAG34985 BAG53227 | ||||||||||||||||||