InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IFRD1

Summary

InnateDB Protein

IDBP-294720.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IFRD1

Protein Name

interferon-related developmental regulator 1

Synonyms

PC4; TIS7;

Species

Homo sapiens

Ensembl Protein

ENSP00000384477

InnateDB Gene

IDBG-36786 (IFRD1)

Protein Structure

UniProt Annotation

Function

Could play a role in regulating gene activity in the proliferative and/or differentiative pathways induced by NGF. May be an autocrine factor that attenuates or amplifies the initial ligand-induced signal (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in a variety of tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding

Biological Process

GO:0007275	multicellular organismal development
GO:0007518	myoblast cell fate determination
GO:0007527	adult somatic muscle development
GO:0042692	muscle cell differentiation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR006921 Interferon-related developmental regulator, C-terminal
IPR007701 Interferon-related developmental regulator, N-terminal
IPR016024 Armadillo-type fold

PFAM

PF04836
PF05004

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00458

PhosphoSite