Version 5.4
Homo sapiens Protein: SUV420H1
Summary
InnateDB Protein IDBP-294729.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUV420H1
Protein Name suppressor of variegation 4-20 homolog 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000385640
InnateDB Gene IDBG-61304 (SUV420H1)
Protein Structure
UniProt Annotation
Function Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. {ECO:0000250, ECO:0000269PubMed:23720823}.
Subcellular Localization Nucleus {ECO:0000269PubMed:23720823}. Chromosome {ECO:0000250}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0018024 histone-lysine N-methyltransferase activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0034773 histone H4-K20 trimethylation
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001214 SET domain
PFAM PF00856
PRINTS
PIRSF
SMART SM00317
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q4FZB7
PhosphoSite PhosphoSite-Q4FZB7
TrEMBL E9PKD9
UniProt Splice Variant
Entrez Gene 51111
UniGene Hs.736528
RefSeq
HUGO HGNC:24283
OMIM 610881
CCDS CCDS44660
HPRD 11616
IMGT
EMBL AF151843 AF264782 AK000046 AL512763 AP002992 BC002522 BC012933 BC065287 BC087834 BC098121 BC099714 BC103498 BC104483
GenPept AAD34080 AAG36937 AAH02522 AAH12933 AAH65287 AAH87834 AAH98121 AAH99714 AAI03499 AAI04484 BAA90905 CAC21680

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca