Version 5.4
Homo sapiens Gene: SUV420H1
Summary
InnateDB Gene IDBG-61304.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUV420H1
Gene Name suppressor of variegation 4-20 homolog 1 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000110066
Encoded Proteins
IDBP-61306
suppressor of variegation 4-20 homolog 1 (Drosophila)
IDBP-61308
suppressor of variegation 4-20 homolog 1 (Drosophila)
IDBP-294746
suppressor of variegation 4-20 homolog 1 (Drosophila)
IDBP-294734
suppressor of variegation 4-20 homolog 1 (Drosophila)
IDBP-294729
suppressor of variegation 4-20 homolog 1 (Drosophila)
IDBP-294748
suppressor of variegation 4-20 homolog 1 (Drosophila)
IDBP-379710
suppressor of variegation 4-20 homolog 1 (Drosophila)
IDBP-379714
suppressor of variegation 4-20 homolog 1 (Drosophila)
IDBP-379725
suppressor of variegation 4-20 homolog 1 (Drosophila)
IDBP-379726
suppressor of variegation 4-20 homolog 1 (Drosophila)
IDBP-379728
suppressor of variegation 4-20 homolog 1 (Drosophila)
IDBP-812370
suppressor of variegation 4-20 homolog 1 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:68154863-68213828
Strand Reverse strand
Band q13.2
Transcripts
ENST00000304363 ENSP00000305899
ENST00000323599 ENSP00000313027
ENST00000402185 ENSP00000384724
ENST00000402789 ENSP00000385005
ENST00000405515 ENSP00000385640
ENST00000401547 ENSP00000385965
ENST00000441488 ENSP00000411146
ENST00000427752 ENSP00000387685
ENST00000453170 ENSP00000406377
ENST00000458496 ENSP00000403233
ENST00000434573 ENSP00000402921
ENST00000466295
ENST00000533271
ENST00000524672
ENST00000615954 ENSP00000484858
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0018024 histone-lysine N-methyltransferase activity
GO:0042799 histone methyltransferase activity (H4-K20 specific)
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016571 histone methylation
GO:0034770 histone H4-K20 methylation
GO:0034773 histone H4-K20 trimethylation
Cellular Component
GO:0000780 condensed nuclear chromosome, centromeric region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000045098
View Gene Order
ENSBTAG00000001185
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
reg_gr_pathway
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.632120 Hs.713195 Hs.736528
RefSeq NM_016028 NM_017635 XM_005274035 XM_005274037 XM_005274038 XM_006718581
HUGO
OMIM
CCDS CCDS31623 CCDS44660
HPRD 11616
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca