InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYCS

Summary

InnateDB Protein

IDBP-294739.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYCS

Protein Name

cytochrome c, somatic

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000387279

InnateDB Gene

IDBG-10008 (CYCS)

Protein Structure

UniProt Annotation

Function

Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases.

Subcellular Localization

Mitochondrion intermembrane space. Note=Loosely associated with the inner membrane.

Disease Associations

Thrombocytopenia 4 (THC4) [MIM:612004]: Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. {ECO:0000269PubMed:18345000}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004722	protein serine/threonine phosphatase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0020037	heme binding
GO:0045155	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity

Biological Process

GO:0006309	apoptotic DNA fragmentation
GO:0006915	apoptotic process
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0016311	dephosphorylation
GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0045333	cellular respiration
GO:0055114	oxidation-reduction process
GO:0097193	intrinsic apoptotic signaling pathway

Cellular Component

GO:0000159	protein phosphatase type 2A complex
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0070469	respiratory chain