InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYCS

Summary

InnateDB Gene

IDBG-10008.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYCS

Gene Name

cytochrome c, somatic

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000172115

Encoded Proteins

IDBP-10010

cytochrome c, somatic

IDBP-294745

cytochrome c, somatic

IDBP-294739

cytochrome c, somatic

IDBP-368744

cytochrome c, somatic

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:25120091-25125361

Strand

Reverse strand

Band

p15.3

Transcripts

ENST00000305786	ENSP00000307786
ENST00000409409	ENSP00000386270
ENST00000409764	ENSP00000387279
ENST00000413447	ENSP00000416479

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	30 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	3 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004722	protein serine/threonine phosphatase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0020037	heme binding
GO:0045155	electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity

Biological Process

GO:0006309	apoptotic DNA fragmentation
GO:0006915	apoptotic process
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0016311	dephosphorylation
GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0045333	cellular respiration
GO:0055114	oxidation-reduction process
GO:0097193	intrinsic apoptotic signaling pathway

Cellular Component

GO:0000159	protein phosphatase type 2A complex
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0070469	respiratory chain