InnateDB Protein
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IDBP-294748.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SUV420H1
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Protein Name
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suppressor of variegation 4-20 homolog 1 (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000385965
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InnateDB Gene
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IDBG-61304 (SUV420H1)
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Protein Structure
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Function |
Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. {ECO:0000250, ECO:0000269PubMed:23720823}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:23720823}. Chromosome {ECO:0000250}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001214
SET domain
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PFAM |
PF00856
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PRINTS |
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PIRSF |
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SMART |
SM00317
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TIGRFAMs |
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Modification |
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SwissProt |
Q4FZB7
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PhosphoSite |
PhosphoSite-Q4FZB7
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TrEMBL |
E9PKD9
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UniProt Splice Variant |
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Entrez Gene |
51111
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UniGene |
Hs.736528
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RefSeq |
NP_057112
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HUGO |
HGNC:24283
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OMIM |
610881
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CCDS |
CCDS44660
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HPRD |
11616
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IMGT |
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EMBL |
AF151843
AF264782
AK000046
AL512763
AP002992
BC002522
BC012933
BC065287
BC087834
BC098121
BC099714
BC103498
BC104483
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GenPept |
AAD34080
AAG36937
AAH02522
AAH12933
AAH65287
AAH87834
AAH98121
AAH99714
AAI03499
AAI04484
BAA90905
CAC21680
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