Version 5.4
Homo sapiens Protein: OSBPL3
Summary
InnateDB Protein IDBP-294755.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSBPL3
Protein Name oxysterol binding protein-like 3
Synonyms ORP-3; ORP3; OSBP3;
Species Homo sapiens
Ensembl Protein ENSP00000386325
InnateDB Gene IDBG-9895 (OSBPL3)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity Isoform 1a, isoform 1b, isoform 1c and isoform 1d are highly expressed in brain, bone marrow, colon, kidney, lung, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart and liver. Isoform 2a, isoform 2b, isoform 2c and isoform 2d are expressed in brain, bone marrow, kidney, skeletal muscle, spleen, thymus and thyroid. Not expressed in heart, liver and lung.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015485 cholesterol binding
Biological Process
GO:0006869 lipid transport
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0097038 perinuclear endoplasmic reticulum
Protein Structure and Domains
PDB ID
InterPro IPR000648 Oxysterol-binding protein
IPR001849 Pleckstrin homology domain
PFAM PF01237
PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H4L5
PhosphoSite PhosphoSite-Q9H4L5
TrEMBL C9JZ19
UniProt Splice Variant
Entrez Gene 26031
UniGene Hs.618931
RefSeq
HUGO HGNC:16370
OMIM 606732
CCDS
HPRD 09474
IMGT
EMBL AB014604 AC003093 AC004008 AC004016 AC004239 AF323727 AF392444 AF491781 AF491782 AF491783 AF491784 AF491785 AF491786 AF515639 AF515640 AY008372 BC017731 CH236948 CH471073
GenPept AAB83939 AAC26986 AAG23400 AAG53408 AAH17731 AAL40657 AAM27386 AAM27387 AAM27388 AAM27389 AAM27390 AAM27391 AAM74165 AAM74166 BAA31679 EAL24240 EAL24241 EAL24242 EAL24243 EAL24244 EAL24245 EAW93816 EAW93817 EAW93818 EAW93819 EAW93820 EAW93821

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca