Version 5.4
Homo sapiens Gene: OSBPL3
Summary
InnateDB Gene IDBG-9895.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSBPL3
Gene Name oxysterol binding protein-like 3
Synonyms ORP-3; ORP3; OSBP3
Species Homo sapiens
Ensembl Gene ENSG00000070882
Encoded Proteins
IDBP-9897
oxysterol binding protein-like 3
IDBP-237466
oxysterol binding protein-like 3
IDBP-237468
oxysterol binding protein-like 3
IDBP-294759
oxysterol binding protein-like 3
IDBP-294768
oxysterol binding protein-like 3
IDBP-294761
oxysterol binding protein-like 3
IDBP-294755
oxysterol binding protein-like 3
IDBP-294753
oxysterol binding protein-like 3
IDBP-368719
oxysterol binding protein-like 3
IDBP-368723
oxysterol binding protein-like 3
IDBP-368727
oxysterol binding protein-like 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Several transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:24796539-24981634
Strand Reverse strand
Band p15.3
Transcripts
ENST00000313367 ENSP00000315410
ENST00000396431 ENSP00000379708
ENST00000396429 ENSP00000379706
ENST00000409069 ENSP00000386953
ENST00000409863 ENSP00000386429
ENST00000409452 ENSP00000386801
ENST00000409759 ENSP00000386325
ENST00000409555 ENSP00000386990
ENST00000415162 ENSP00000407829
ENST00000441059 ENSP00000403374
ENST00000415952 ENSP00000411249
ENST00000487020
ENST00000459987
ENST00000461835
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015485 cholesterol binding
Biological Process
GO:0006869 lipid transport
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0097038 perinuclear endoplasmic reticulum
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029822
View Gene Order
ENSBTAG00000019342
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.520259 Hs.593705 Hs.618931
RefSeq NM_015550 NM_145320 NM_145321 NM_145322 XM_005249698 XM_006715681 XM_006715682 XM_006715683 XM_006715684
HUGO
OMIM
CCDS CCDS47564 CCDS5390 CCDS5391 CCDS5392
HPRD 09474
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca