Version 5.4
Homo sapiens Protein: PLIN1
Summary
InnateDB Protein IDBP-29479.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLIN1
Protein Name perilipin 1
Synonyms FPLD4; PERI; PLIN;
Species Homo sapiens
Ensembl Protein ENSP00000300055
InnateDB Gene IDBG-29477 (PLIN1)
Protein Structure
UniProt Annotation
Function Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone- sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. {ECO:0000269PubMed:23399566}.
Subcellular Localization Endoplasmic reticulum {ECO:0000269PubMed:23399566}. Lipid droplet {ECO:0000269PubMed:23399566}. Note=Lipid droplet surface- associated.
Disease Associations Lipodystrophy, familial partial, 4 (FPLD4) [MIM:613877]: A form of lipodystrophy characterized by loss of subcutaneous adipose tissue primarily affecting the lower limbs, insulin- resistant diabetes mellitus, hypertriglyceridemia, and hypertension. {ECO:0000269PubMed:21345103}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Adipocytes. {ECO:0000269PubMed:9521880}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0006629 lipid metabolic process
GO:0016042 lipid catabolic process
GO:0019433 triglyceride catabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005811 lipid particle
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR004279 Perilipin
PFAM PF03036
PRINTS
PIRSF PIRSF036881
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O60240
PhosphoSite PhosphoSite-O60240
TrEMBL
UniProt Splice Variant
Entrez Gene 5346
UniGene Hs.712997
RefSeq NP_002657
HUGO HGNC:9076
OMIM 170290
CCDS CCDS10353
HPRD 01364
IMGT
EMBL AB005293 AC013787 BC031084
GenPept AAH31084 BAA25420

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca