InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PLIN1

Summary

InnateDB Gene

IDBG-29477.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLIN1

Gene Name

perilipin 1

Synonyms

FPLD4; PERI; PLIN

Species

Homo sapiens

Ensembl Gene

ENSG00000166819

Encoded Proteins

IDBP-29479

perilipin 1

IDBP-380199

perilipin 1

IDBP-592412

perilipin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Feb 2009]
The protein encoded by this gene coats lipid storage droplets in adipocytes, thereby protecting them until they can be broken down by hormone-sensitive lipase. The encoded protein is the major cAMP-dependent protein kinase substrate in adipocytes and, when unphosphorylated, may play a role in the inhibition of lipolysis. Alternatively spliced transcript variants varying in the 5\' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:89664365-89679427

Strand

Reverse strand

Band

q26.1

Transcripts

ENST00000300055	ENSP00000300055
ENST00000430628	ENSP00000402167
ENST00000560330	ENSP00000453426
ENST00000531697

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008289	lipid binding

Biological Process

GO:0006629	lipid metabolic process
GO:0016042	lipid catabolic process
GO:0019433	triglyceride catabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005811	lipid particle
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030546

View Gene Order

ENSBTAG00000015350

Not yet available

Pathways

NETPATH

REACTOME

REACT_494

Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis pathway

REACT_27161

Transcriptional regulation of white adipocyte differentiation pathway

REACT_111045

Developmental Biology pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

REACT_602

Lipid digestion, mobilization, and transport pathway

KEGG

hsa03320

PPAR signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.103253 Hs.712997

RefSeq

NM_001145311 NM_002666 XM_005254934

HUGO

OMIM

CCDS

CCDS10353

HPRD

01364

IMGT

EMBL

GenPept

RNA Seq Atlas