InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: F11

Summary

InnateDB Protein

IDBP-294810.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

F11

Protein Name

coagulation factor XI

Synonyms

FXI;

Species

Homo sapiens

Ensembl Protein

ENSP00000384957

InnateDB Gene

IDBG-47627 (F11)

Protein Structure

UniProt Annotation

Function

Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.

Subcellular Localization

Secreted.

Disease Associations

Factor XI deficiency (FA11D) [MIM:612416]: A hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate. {ECO:0000269PubMed:10027710, ECO:0000269PubMed:10606881, ECO:0000269PubMed:11895778, ECO:0000269PubMed:15026311, ECO:0000269PubMed:15180874, ECO:0000269PubMed:1547342, ECO:0000269PubMed:15953011, ECO:0000269PubMed:16607084, ECO:0000269PubMed:18005151, ECO:0000269PubMed:21457405, ECO:0000269PubMed:21668437, ECO:0000269PubMed:21999818, ECO:0000269PubMed:22016685, ECO:0000269PubMed:22159456, ECO:0000269PubMed:22322133, ECO:0000269PubMed:2813350, ECO:0000269PubMed:7669672, ECO:0000269PubMed:7888672, ECO:0000269PubMed:9401068, ECO:0000269PubMed:9787168}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0070009	serine-type aminopeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0007596	blood coagulation
GO:0007597	blood coagulation, intrinsic pathway
GO:0030193	regulation of blood coagulation
GO:0031639	plasminogen activation
GO:0045087	innate immune response (InnateDB)
GO:0051919	positive regulation of fibrinolysis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000177 Apple domain
IPR001254 Peptidase S1
IPR001314 Peptidase S1A, chymotrypsin-type
IPR003014 PAN-1 domain
IPR003609 Apple-like
IPR009003 Trypsin-like cysteine/serine peptidase domain

PFAM

PF00089
PF00024

PRINTS

PR00005
PR00722

PIRSF

SMART

SM00223
SM00020
SM00473

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt