InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCOA1

Summary

InnateDB Protein

IDBP-294848.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCOA1

Protein Name

nuclear receptor coactivator 1

Synonyms

bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160; SRC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000385195

InnateDB Gene

IDBG-33884 (NCOA1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 169 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	169 [view]
Protein-Protein	150 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	10 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0004871	signal transducer activity
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0035257	nuclear hormone receptor binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0016573	histone acetylation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000014 PAS domain
IPR009110 Nuclear receptor coactivator, interlocking
IPR010011 Domain of unknown function DUF1518
IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
IPR014935 Steroid receptor coactivator

PFAM

PF13188
PF13426
PF07469
PF08815
PF08832

PRINTS

PIRSF

SMART

SM00091

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite