InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCOA1

Summary

InnateDB Protein

IDBP-294861.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCOA1

Protein Name

nuclear receptor coactivator 1

Synonyms

bHLHe42; bHLHe74; F-SRC-1; KAT13A; RIP160; SRC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000385216

InnateDB Gene

IDBG-33884 (NCOA1)

Protein Structure

UniProt Annotation

Function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4; the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. {ECO:0000269PubMed:10449719, ECO:0000269PubMed:12954634, ECO:0000269PubMed:7481822, ECO:0000269PubMed:9223281, ECO:0000269PubMed:9223431, ECO:0000269PubMed:9296499, ECO:0000269PubMed:9427757}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.

Disease Associations

Note=A chromosomal aberration involving NCOA1 is a cause of rhabdomyosarcoma. Translocation t(2;2)(q35;p23) with PAX3 generates the NCOA1-PAX3 oncogene consisting of the N-terminus part of PAX3 and the C-terminus part of NCOA1. The fusion protein acts as a transcriptional activator. Rhabdomyosarcoma is the most common soft tissue carcinoma in childhood, representing 5-8% of all malignancies in children.

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:15313887, ECO:0000269PubMed:9427757}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 169 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	169 [view]
Protein-Protein	150 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	10 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001012	RNA polymerase II regulatory region DNA binding
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0019899	enzyme binding
GO:0030331	estrogen receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0032403	protein complex binding
GO:0033142	progesterone receptor binding
GO:0035257	nuclear hormone receptor binding
GO:0042974	retinoic acid receptor binding
GO:0046965	retinoid X receptor binding
GO:0046983	protein dimerization activity
GO:0047485	protein N-terminus binding
GO:0050681	androgen receptor binding

Biological Process

GO:0000435	positive regulation of transcription from RNA polymerase II promoter by galactose
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0007595	lactation
GO:0008584	male gonad development
GO:0009725	response to hormone
GO:0021549	cerebellum development
GO:0021766	hippocampus development
GO:0021854	hypothalamus development
GO:0021987	cerebral cortex development
GO:0030521	androgen receptor signaling pathway
GO:0032355	response to estradiol
GO:0032526	response to retinoic acid
GO:0032570	response to progesterone
GO:0032870	cellular response to hormone stimulus
GO:0042698	ovulation cycle
GO:0043065	positive regulation of apoptotic process
GO:0043967	histone H4 acetylation
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045666	positive regulation of neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045925	positive regulation of female receptivity
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060179	male mating behavior
GO:0060206	estrous cycle phase
GO:0060713	labyrinthine layer morphogenesis
GO:2001038	regulation of cellular response to drug
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

InterPro

IPR000014 PAS domain
IPR009110 Nuclear receptor coactivator, interlocking
IPR010011 Domain of unknown function DUF1518
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013767 PAS fold
IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
IPR014935 Steroid receptor coactivator
IPR017426 Nuclear receptor coactivator

PFAM