InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TFIP11

Summary

InnateDB Protein

IDBP-294875.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TFIP11

Protein Name

tuftelin interacting protein 11

Synonyms

bK445C9.6; hNtr1; NTR1; Spp382; TIP39;

Species

Homo sapiens

Ensembl Protein

ENSP00000383892

InnateDB Gene

IDBG-3198 (TFIP11)

Protein Structure

UniProt Annotation

Function

Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. {ECO:0000269PubMed:19103666}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the nucleus localizes to unique speckle domains in close proximity to nuclear speckles and not identical to paraspeckles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	32 [view]
Protein-Protein	31 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding

Biological Process

GO:0000390	spliceosomal complex disassembly
GO:0000398	mRNA splicing, via spliceosome
GO:0006355	regulation of transcription, DNA-templated
GO:0006396	RNA processing
GO:0031214	biomineral tissue development

Cellular Component

GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0016607	nuclear speck
GO:0071008	U2-type post-mRNA release spliceosomal complex
GO:0071013	catalytic step 2 spliceosome