InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITSN2

Summary

InnateDB Protein

IDBP-294883.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITSN2

Protein Name

intersectin 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000384499

InnateDB Gene

IDBG-33600 (ITSN2)

Protein Structure

UniProt Annotation

Function

Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). {ECO:0000269PubMed:19458185, ECO:0000269PubMed:22648170}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitous. Isoform 1 is primarily expressed in adult heart and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.

Experimentally validated
Total	86 [view]
Protein-Protein	86 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0006897	endocytosis
GO:0009967	positive regulation of signal transduction
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction