Version 5.4
Homo sapiens Gene: ITSN2
Summary
InnateDB Gene IDBG-33600.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITSN2
Gene Name intersectin 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198399
Encoded Proteins
IDBP-33604
intersectin 2
IDBP-33606
intersectin 2
IDBP-294883
intersectin 2
IDBP-366373
intersectin 2
IDBP-366378
intersectin 2
IDBP-366380
intersectin 2
IDBP-366383
intersectin 2
IDBP-366387
intersectin 2
IDBP-811470
intersectin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:24202864-24360714
Strand Reverse strand
Band p23.3
Transcripts
ENST00000361999 ENSP00000354561
ENST00000355123 ENSP00000347244
ENST00000406921 ENSP00000384499
ENST00000407704
ENST00000427234 ENSP00000395682
ENST00000449392 ENSP00000411319
ENST00000416160 ENSP00000389013
ENST00000412011 ENSP00000391224
ENST00000443927 ENSP00000391715
ENST00000478720
ENST00000479575
ENST00000469848
ENST00000622089 ENSP00000479408
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
Experimentally validated
Total 86 [view]
Protein-Protein 86 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0006897 endocytosis
GO:0009967 positive regulation of signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020640
View Gene Order
ENSBTAG00000023172
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
NetPath_24
TSLP pathway
REACTOME
KEGG
INOH
PID NCI
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.432562 Hs.458901 Hs.562584 Hs.673718
RefSeq NM_006277 NM_019595 NM_147152
HUGO
OMIM
CCDS CCDS1710 CCDS1711 CCDS46230
HPRD 09193
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca