InnateDB Protein
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IDBP-294948.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LIMS1
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Protein Name
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LIM and senescent cell antigen-like domains 1
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Synonyms
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PINCH; PINCH-1; PINCH1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000387264
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InnateDB Gene
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IDBG-65056 (LIMS1)
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Protein Structure
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Function |
Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.
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Subcellular Localization |
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
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Disease Associations |
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Tissue Specificity |
Expressed in most tissues except in the brain.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
27
[view]
|
Protein-Protein |
26
[view]
|
Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001781
Zinc finger, LIM-type
IPR017351
LIM and senescent cell antigen-like-containing domain protein 1
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PFAM |
PF00412
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PRINTS |
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PIRSF |
PIRSF038003
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SMART |
SM00132
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TIGRFAMs |
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Modification |
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SwissProt |
P48059
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PhosphoSite |
PhosphoSite-P48059
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TrEMBL |
F8WB59
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UniProt Splice Variant |
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Entrez Gene |
3987
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UniGene |
Hs.714056
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RefSeq |
NP_001180413
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HUGO |
HGNC:6616
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OMIM |
602567
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CCDS |
CCDS54384
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HPRD |
03978
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IMGT |
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EMBL |
AC010095
AC012487
AK296992
AK302411
AK304260
AK314217
BC005341
U09284
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GenPept |
AAA20086
AAH05341
AAY14983
BAG36891
BAH12469
BAH13699
BAH14143
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