InnateDB Protein
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IDBP-294956.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PLEKHG2
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Protein Name
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pleckstrin homology domain containing, family G (with RhoGef domain) member 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000386492
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InnateDB Gene
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IDBG-50331 (PLEKHG2)
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Protein Structure
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Function |
May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide- binding protein (G protein). {ECO:0000250, ECO:0000269PubMed:18045877}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005089
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Rho guanyl-nucleotide exchange factor activity
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Biological Process |
GO:0007264
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small GTPase mediated signal transduction
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GO:0032321
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positive regulation of Rho GTPase activity
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GO:0035023
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regulation of Rho protein signal transduction
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GO:0043065
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positive regulation of apoptotic process
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GO:0048011
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neurotrophin TRK receptor signaling pathway
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GO:0051056
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regulation of small GTPase mediated signal transduction
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GO:0097190
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apoptotic signaling pathway
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Cellular Component |
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PDB ID |
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InterPro |
IPR000219
Dbl homology (DH) domain
IPR001849
Pleckstrin homology domain
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PFAM |
PF00621
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00325
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H7P9
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PhosphoSite |
PhosphoSite-Q9H7P9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
64857
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UniGene |
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RefSeq |
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HUGO |
HGNC:29515
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OMIM |
611893
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CCDS |
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HPRD |
15148
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IMGT |
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EMBL |
AC011500
AK024429
AK026111
BC013426
BC015174
BC075858
CH471126
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GenPept |
AAH13426
AAH15174
AAH75858
BAB15364
BAB15719
EAW56888
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