Homo sapiens Gene: PLEKHG2
Summary
InnateDB Gene IDBG-50331.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLEKHG2
Gene Name pleckstrin homology domain containing, family G (with RhoGef domain) member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000090924
Encoded Proteins
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
pleckstrin homology domain containing, family G (with RhoGef domain) member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:39412585-39428415
Strand Forward strand
Band q13.2
Transcripts
ENST00000205135 ENSP00000205135
ENST00000409797 ENSP00000386492
ENST00000425673 ENSP00000392906
ENST00000458508 ENSP00000408857
ENST00000438123 ENSP00000397615
ENST00000451354 ENSP00000412818
ENST00000478523
ENST00000474449
ENST00000598238 ENSP00000473213
ENST00000600210 ENSP00000473251
ENST00000594124 ENSP00000472989
ENST00000596443 ENSP00000468829
ENST00000594307
ENST00000595920 ENSP00000473068
ENST00000594161 ENSP00000471460
ENST00000596339 ENSP00000470763
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase mediated signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
NRAGE signals death through JNK pathway
G alpha (12/13) signalling events pathway
Rho GTPase cycle pathway
Signalling by NGF pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL M0QX05
UniProt Splice Variant
Entrez Gene 64857
UniGene
RefSeq NM_022835 XM_005259163 XM_006723332 XM_006723333
HUGO HGNC:29515
OMIM 611893
CCDS CCDS33022
HPRD 15148
IMGT
EMBL AC011500
GenPept
RNA Seq Atlas 64857