InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ST6GAL2

Summary

InnateDB Protein

IDBP-294993.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ST6GAL2

Protein Name

ST6 beta-galactosamide alpha-2,6-sialyltranferase 2

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000387332

InnateDB Gene

IDBG-64788 (ST6GAL2)

Protein Structure

UniProt Annotation

Function

Transfers sialic acid from the donor of substrate CMP- sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.

Subcellular Localization

Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Weakly expressed in some tissues, such as small intestine, colon and fetal brain. {ECO:0000269PubMed:12235148, ECO:0000269PubMed:12603328}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003835	beta-galactoside alpha-2,6-sialyltransferase activity
GO:0008373	sialyltransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006486	protein glycosylation
GO:0007275	multicellular organismal development
GO:0009311	oligosaccharide metabolic process
GO:0040007	growth
GO:0097503	sialylation