Version 5.4
Homo sapiens Gene: ST6GAL2
Summary
InnateDB Gene IDBG-64788.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST6GAL2
Gene Name ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000144057
Encoded Proteins
IDBP-64790
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
IDBP-64792
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
IDBP-294995
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
IDBP-294993
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
IDBP-384198
ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus encodes a sialyltransferase. The encoded type II transmembrane protein catalyzes the transfer of sialic acid from CMP to an oligosaccharide substrate. Polymorphisms at this locus may be associated with variations in risperidone response in schizophrenic patients. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:106801600-106887108
Strand Reverse strand
Band q12.3
Transcripts
ENST00000361686 ENSP00000355273
ENST00000361803 ENSP00000355386
ENST00000409382 ENSP00000386942
ENST00000409087 ENSP00000387332
ENST00000419159 ENSP00000395581
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0007275 multicellular organismal development
GO:0009311 oligosaccharide metabolic process
GO:0040007 growth
GO:0097503 sialylation
Cellular Component
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024172
View Gene Order
ENSBTAG00000000703
Not yet available
Pathways
NETPATH
REACTOME
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_200874
Sialic acid metabolism pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
hsa00514
Other types of O-glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9JIK2
UniProt Splice Variant
Entrez Gene 84620
UniGene Hs.609912 Hs.98265
RefSeq NM_001142351 NM_001142352 NM_032528 XM_006712801 XM_006712802
HUGO HGNC:10861
OMIM 608472
CCDS CCDS2073 CCDS46380
HPRD 12237
IMGT
EMBL AC005040 AC016994 AC108049
GenPept
RNA Seq Atlas 84620

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca