InnateDB Protein
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IDBP-294995.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ST6GAL2
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Protein Name
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ST6 beta-galactosamide alpha-2,6-sialyltranferase 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000386942
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InnateDB Gene
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IDBG-64788 (ST6GAL2)
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Protein Structure
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Function |
Transfers sialic acid from the donor of substrate CMP- sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.
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Subcellular Localization |
Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Weakly expressed in some tissues, such as small intestine, colon and fetal brain. {ECO:0000269PubMed:12235148, ECO:0000269PubMed:12603328}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0003824
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catalytic activity
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GO:0003835
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beta-galactoside alpha-2,6-sialyltransferase activity
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GO:0008373
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sialyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001675
Glycosyl transferase, family 29
IPR011330
Glycoside hydrolase/deacetylase, beta/alpha-barrel
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PFAM |
PF00777
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96JF0
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PhosphoSite |
PhosphoSite-Q96JF0
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TrEMBL |
C9JIK2
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UniProt Splice Variant |
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Entrez Gene |
84620
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UniGene |
Hs.98265
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RefSeq |
NP_001135823
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HUGO |
HGNC:10861
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OMIM |
608472
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CCDS |
CCDS2073
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HPRD |
12237
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IMGT |
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EMBL |
AB058780
AB059555
AC005040
AC016994
AC108049
AJ512141
BC008680
CH471127
FJ433883
FJ433884
FJ433885
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GenPept |
AAH08680
AAY15022
ACQ63561
ACQ63562
ACQ63563
BAB47506
BAC24793
CAD54408
EAX01742
EAX01743
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