Version 5.4
Homo sapiens Protein: UXS1
Summary
InnateDB Protein IDBP-294999.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UXS1
Protein Name UDP-glucuronate decarboxylase 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000387096
InnateDB Gene IDBG-64692 (UXS1)
Protein Structure
UniProt Annotation
Function Catalyzes the NAD-dependent decarboxylation of UDP- glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
Subcellular Localization Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0042803 protein homodimerization activity
GO:0048040 UDP-glucuronate decarboxylase activity
GO:0050662 coenzyme binding
GO:0070403 NAD+ binding
Biological Process
GO:0033320 UDP-D-xylose biosynthetic process
GO:0044237 cellular metabolic process
GO:0051262 protein tetramerization
Cellular Component
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
IPR005913 dTDP-4-dehydrorhamnose reductase
IPR013120 Male sterility, NAD-binding
PFAM PF01370
PF04321
PF07993
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NBZ7
PhosphoSite PhosphoSite-Q8NBZ7
TrEMBL Q8ND26
UniProt Splice Variant
Entrez Gene 80146
UniGene Hs.743389
RefSeq NP_001240805
HUGO HGNC:17729
OMIM 609749
CCDS CCDS58720
HPRD 15642
IMGT
EMBL AC018878 AK027244 AK075120 AK075170 AL834439 AY147934 AY358541 BC009819
GenPept AAH09819 AAN39844 AAQ88905 AAY15085 BAB15705 BAC11415 BAC11448 CAD39099

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca