Version 5.4
Homo sapiens Gene: UXS1
Summary
InnateDB Gene IDBG-64692.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UXS1
Gene Name UDP-glucuronate decarboxylase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000115652
Encoded Proteins
IDBP-64694
UDP-glucuronate decarboxylase 1
IDBP-295001
UDP-glucuronate decarboxylase 1
IDBP-294999
UDP-glucuronate decarboxylase 1
IDBP-384144
UDP-glucuronate decarboxylase 1
IDBP-384145
UDP-glucuronate decarboxylase 1
IDBP-384146
UDP-glucuronate decarboxylase 1
IDBP-384147
UDP-glucuronate decarboxylase 1
IDBP-384151
UDP-glucuronate decarboxylase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enyzme found in the perinuclear Golgi which catalyzes the synthesis of UDP-xylose used in glycosaminoglycan (GAG) synthesis on proteoglycans. The GAG chains are covalently attached to proteoglycans which participate in signaling pathways during development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:106093303-106194339
Strand Reverse strand
Band q12.2
Transcripts
ENST00000283148 ENSP00000283148
ENST00000409501 ENSP00000387019
ENST00000409032 ENSP00000387096
ENST00000441952 ENSP00000416656
ENST00000416298 ENSP00000403612
ENST00000444193 ENSP00000404468
ENST00000457835 ENSP00000399316
ENST00000436241 ENSP00000397049
ENST00000497604
ENST00000473338
ENST00000470053
ENST00000479621
ENST00000479774
ENST00000483426
ENST00000474920
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803 protein homodimerization activity
GO:0048040 UDP-glucuronate decarboxylase activity
GO:0050662 coenzyme binding
GO:0070403 NAD+ binding
Biological Process
GO:0006694 steroid biosynthetic process
GO:0009058 biosynthetic process
GO:0033320 UDP-D-xylose biosynthetic process
GO:0044237 cellular metabolic process
GO:0051262 protein tetramerization
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000057363
View Gene Order
ENSBTAG00000005614
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
hsa00500
Starch and sucrose metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.730756 Hs.743389
RefSeq NM_001253875 NM_001253876 NM_025076
HUGO
OMIM
CCDS CCDS46378 CCDS58720 CCDS58721
HPRD 15642
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca