InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UXS1

Summary

InnateDB Protein

IDBP-295001.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UXS1

Protein Name

UDP-glucuronate decarboxylase 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000387019

InnateDB Gene

IDBG-64692 (UXS1)

Protein Structure

UniProt Annotation

Function

Catalyzes the NAD-dependent decarboxylation of UDP- glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.

Subcellular Localization

Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803	protein homodimerization activity
GO:0048040	UDP-glucuronate decarboxylase activity
GO:0050662	coenzyme binding
GO:0070403	NAD+ binding

Biological Process

GO:0006694	steroid biosynthetic process
GO:0033320	UDP-D-xylose biosynthetic process
GO:0044237	cellular metabolic process
GO:0051262	protein tetramerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0016021	integral component of membrane
GO:0032580	Golgi cisterna membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001509 NAD-dependent epimerase/dehydratase, N-terminal domain
IPR002225 3-beta hydroxysteroid dehydrogenase/isomerase
IPR005913 dTDP-4-dehydrorhamnose reductase
IPR013120 Male sterility, NAD-binding
IPR021761 UDP-glucuronate decarboxylase N-terminal

PFAM

PF01370
PF01073
PF04321
PF07993
PF11803

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8NBZ7

PhosphoSite