InnateDB Protein
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IDBP-295062.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SMC6
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Protein Name
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structural maintenance of chromosomes 6
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000384539
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InnateDB Gene
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IDBG-31220 (SMC6)
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Protein Structure
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Function |
Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. {ECO:0000269PubMed:16810316, ECO:0000269PubMed:17589526}.
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Subcellular Localization |
Nucleus. Chromosome. Chromosome, telomere. Note=Associates with chromatin. Localizes to PML nuclear bodies in ALT cell lines.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Overexpressed in testis. {ECO:0000269PubMed:11408570}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003395
RecF/RecN/SMC, N-terminal
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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PFAM |
PF02463
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96SB8
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PhosphoSite |
PhosphoSite-Q96SB8
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TrEMBL |
C9JEF0
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UniProt Splice Variant |
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Entrez Gene |
79677
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UniGene |
Hs.733296
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RefSeq |
XP_006712166
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HUGO |
HGNC:20466
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OMIM |
609387
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CCDS |
CCDS1690
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HPRD |
10242
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IMGT |
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EMBL |
AC093731
AC097377
AJ310551
AK025769
AK292421
AL136544
AL832979
BC032675
BC039828
CH471053
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GenPept |
AAH32675
AAH39828
AAX88851
BAB15236
BAF85110
CAB66479
CAC39248
CAH56327
EAX00866
EAX00867
EAX00868
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