InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLDN15

Summary

InnateDB Protein

IDBP-295123.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLDN15

Protein Name

claudin 15

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000385300

InnateDB Gene

IDBG-33221 (CLDN15)

Protein Structure

UniProt Annotation

Function

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members function as impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN15 forms tight junctions that mediate the paracellular transport of small monovalent cations along a concentration gradient, due to selective permeability for Na(+), Li(+) and K(+) ions, but selects against Cl(-) ions. Plays an important role in paracellular Na(+) transport in the intestine and in Na(+) homeostasis. Required for normal Na(+)-dependent intestinal nutrient uptake. {ECO:0000269PubMed:12055082, ECO:0000269PubMed:13129853}.

Subcellular Localization

Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Tight junctions form continuous circumferential cell-cell contacts at the borders of apical and lateral cell membranes that seal the intercellular space and show up as strand-like structures in electron microscopy.

Disease Associations

Tissue Specificity

Detected in colon (at protein level). {ECO:0000269PubMed:12055082}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0042802	identical protein binding

Biological Process

GO:0006811	ion transport
GO:0016338	calcium-independent cell-cell adhesion
GO:0034329	cell junction assembly
GO:0045216	cell-cell junction organization
GO:0070830	tight junction assembly