Version 5.4
Homo sapiens Protein: AFF3
Summary
InnateDB Protein IDBP-295162.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AFF3
Protein Name AF4/FMR2 family, member 3
Synonyms LAF4; MLLT2-like;
Species Homo sapiens
Ensembl Protein ENSP00000386834
InnateDB Gene IDBG-63454 (AFF3)
Protein Structure
UniProt Annotation
Function Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double- stranded DNA.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Preferentially expressed in lymphoid tissues, highest levels being found in the thymus.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003690 double-stranded DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0034612 response to tumor necrosis factor
GO:0035116 embryonic hindlimb morphogenesis
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007797 Transcription factor AF4/FMR2
PFAM PF05110
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P51826
PhosphoSite PhosphoSite-P51826
TrEMBL
UniProt Splice Variant
Entrez Gene 3899
UniGene Hs.617645
RefSeq NP_001020279
HUGO HGNC:6473
OMIM 601464
CCDS CCDS33258
HPRD 03272
IMGT
EMBL AB209634 AC010736 AC018690 AC073118 AC092667 BC036895 BC136579 BC144266 CH471127 U34360
GenPept AAA98763 AAH36895 AAI36580 AAI44267 AAY14792 AAY24187 AAY24278 AAY24315 BAD92871 EAX01854 EAX01855 EAX01856 EAX01857 EAX01858 EAX01859

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca