Version 5.4
Homo sapiens Gene: AFF3
Summary
InnateDB Gene IDBG-63454.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AFF3
Gene Name AF4/FMR2 family, member 3
Synonyms LAF4; MLLT2-like
Species Homo sapiens
Ensembl Gene ENSG00000144218
Encoded Proteins
IDBP-63458
AF4/FMR2 family, member 3
IDBP-295162
AF4/FMR2 family, member 3
IDBP-295160
AF4/FMR2 family, member 3
IDBP-383590
AF4/FMR2 family, member 3
IDBP-383593
AF4/FMR2 family, member 3
IDBP-383594
AF4/FMR2 family, member 3
IDBP-383595
AF4/FMR2 family, member 3
IDBP-383596
AF4/FMR2 family, member 3
IDBP-383600
AF4/FMR2 family, member 3
IDBP-383601
AF4/FMR2 family, member 3
IDBP-383602
AF4/FMR2 family, member 3
IDBP-383604
AF4/FMR2 family, member 3
IDBP-383606
AF4/FMR2 family, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:99545419-100142739
Strand Reverse strand
Band q11.2
Transcripts
ENST00000317233 ENSP00000317421
ENST00000409579 ENSP00000386834
ENST00000409236 ENSP00000387207
ENST00000445815 ENSP00000416685
ENST00000430789 ENSP00000414099
ENST00000432037 ENSP00000406484
ENST00000423966 ENSP00000396582
ENST00000441400 ENSP00000399795
ENST00000424600 ENSP00000411383
ENST00000416492 ENSP00000395068
ENST00000440445 ENSP00000393732
ENST00000415384 ENSP00000407448
ENST00000427118 ENSP00000416131
ENST00000498090
ENST00000483600
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003690 double-stranded DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0034612 response to tumor necrosis factor
GO:0035116 embryonic hindlimb morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037138
View Gene Order
ENSBTAG00000012449
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.444414 Hs.617645
RefSeq NM_001025108 NM_002285 XM_005263942 XM_005263943 XM_005263945
HUGO
OMIM
CCDS CCDS33258 CCDS42723
HPRD 03272
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca