InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TONSL

Summary

InnateDB Protein

IDBP-295197.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TONSL

Protein Name

tonsoku-like, DNA repair protein

Synonyms

IKBR; NFKBIL2;

Species

Homo sapiens

Ensembl Protein

ENSP00000386239

InnateDB Gene

IDBG-40948 (TONSL)

Protein Structure

UniProt Annotation

Function

Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold. {ECO:0000269PubMed:21055983, ECO:0000269PubMed:21055984, ECO:0000269PubMed:21055985, ECO:0000269PubMed:7738005}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Mainly nuclear. Localizes to DNA damage sites, accumulates at stressed replication forks.

Disease Associations

Tissue Specificity

Expressed in heart, skeletal muscle and tracheal epithelial cells. {ECO:0000269PubMed:7738005}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042393	histone binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0031297	replication fork processing
GO:0042994	cytoplasmic sequestering of transcription factor
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005662	DNA replication factor A complex
GO:0005737	cytoplasm
GO:0035101	FACT complex
GO:0042555	MCM complex
GO:0043596	nuclear replication fork

Protein Structure and Domains

PDB ID

InterPro

IPR002110 Ankyrin repeat
IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat
IPR020683 Ankyrin repeat-containing domain

PFAM