Version 5.4
Homo sapiens Gene: TONSL
Summary
InnateDB Gene IDBG-40948.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TONSL
Gene Name tonsoku-like, DNA repair protein
Synonyms IKBR; NFKBIL2
Species Homo sapiens
Ensembl Gene ENSG00000160949
Encoded Proteins
IDBP-295197
tonsoku-like, DNA repair protein
IDBP-808517
tonsoku-like, DNA repair protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:144428775-144444444
Strand Reverse strand
Band q24.3
Transcripts
ENST00000409379 ENSP00000386239
ENST00000497613
ENST00000613741 ENSP00000484162
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0042393 histone binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0031297 replication fork processing
GO:0042994 cytoplasmic sequestering of transcription factor
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005662 DNA replication factor A complex
GO:0005737 cytoplasm
GO:0035101 FACT complex
GO:0042555 MCM complex
GO:0043596 nuclear replication fork
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000059323
View Gene Order
ENSBTAG00000007749
Not yet available
Cross-References
SwissProt Q96HA7
TrEMBL
UniProt Splice Variant
Entrez Gene 4796
UniGene Hs.675285
RefSeq NM_013432 XM_005272321
HUGO HGNC:7801
OMIM 604546
CCDS CCDS34968
HPRD
IMGT
EMBL AC084125 AF205589 AJ249601 BC008782 U16258
GenPept AAA85819 AAH08782 CAB63467
RNA Seq Atlas 4796

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca