InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ETV2

Summary

InnateDB Protein

IDBP-295247.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ETV2

Protein Name

ets variant 2

Synonyms

ER71; ETSRP71;

Species

Homo sapiens

Ensembl Protein

ENSP00000384524

InnateDB Gene

IDBG-44778 (ETV2)

Protein Structure

UniProt Annotation

Function

Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'. {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001701	in utero embryonic development
GO:0001707	mesoderm formation
GO:0001824	blastocyst development
GO:0001890	placenta development
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007219	Notch signaling pathway
GO:0010628	positive regulation of gene expression
GO:0016055	Wnt signaling pathway
GO:0030097	hemopoiesis
GO:0030154	cell differentiation
GO:0030218	erythrocyte differentiation
GO:0045603	positive regulation of endothelial cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048514	blood vessel morphogenesis
GO:0060803	BMP signaling pathway involved in mesodermal cell fate specification
GO:2000382	positive regulation of mesoderm development