InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APOPT1

Summary

InnateDB Protein

IDBP-295306.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOPT1

Protein Name

apoptogenic 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000386485

InnateDB Gene

IDBG-547131 (APOPT1)

Protein Structure

UniProt Annotation

Function

Plays a role in the regulation of apoptosis. Mediates mitochondria-induced cell death in vascular smooth muscle cells through the release of cytochrome c from mitochondria, followed by the activation of the caspase cascade (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0008629	induction of apoptosis by intracellular signals
GO:0034393	positive regulation of smooth muscle cell apoptotic process
GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097193	intrinsic apoptotic signaling pathway