InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CPQ

Summary

InnateDB Protein

IDBP-29542.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CPQ

Protein Name

Plasma glutamate carboxypeptidase

Synonyms

LDP; PGCP;

Species

Homo sapiens

Ensembl Protein

ENSP00000220763

InnateDB Gene

IDBG-29540 (CPQ)

Protein Structure

UniProt Annotation

Function

Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.

Subcellular Localization

Endoplasmic reticulum {ECO:0000269PubMed:10206990}. Golgi apparatus {ECO:0000269PubMed:10206990}. Lysosome {ECO:0000250}. Secreted {ECO:0000269PubMed:10206990}. Note=Secretion is stimulated by TSH/thyroid-stimulating hormone, INS/insulin and SST/somatostatin. {ECO:0000250}.

Disease Associations

Tissue Specificity

Mainly detected in blood plasma. Abundant in placenta and kidney. Present at low level in muscles, liver and skin fibroblasts. Not detected in brain or white blood cells (at protein level). {ECO:0000269PubMed:10206990}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004180	carboxypeptidase activity
GO:0016787	hydrolase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0070573	metallodipeptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006590	thyroid hormone generation
GO:0008152	metabolic process
GO:0042246	tissue regeneration
GO:0043171	peptide catabolic process

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0070062	extracellular vesicular exosome