InnateDB Protein
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IDBP-295446.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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LRRTM4
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Protein Name
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leucine rich repeat transmembrane neuronal 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000386357
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InnateDB Gene
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IDBG-58344 (LRRTM4)
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Protein Structure
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Function |
May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in neuronal tissues. {ECO:0000269PubMed:12676565}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0072578
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neurotransmitter-gated ion channel clustering
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GO:0097113
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alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering
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GO:1901629
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regulation of presynaptic membrane organization
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Cellular Component |
GO:0030054
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cell junction
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GO:0032281
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alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
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GO:0045211
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postsynaptic membrane
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PDB ID |
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InterPro |
IPR001611
Leucine-rich repeat
IPR003591
Leucine-rich repeat, typical subtype
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PFAM |
PF00560
PF13504
PF13855
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PRINTS |
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PIRSF |
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SMART |
SM00369
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TIGRFAMs |
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Modification |
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SwissProt |
Q86VH4
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PhosphoSite |
PhosphoSite-Q86VH4
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TrEMBL |
C9JM64
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UniProt Splice Variant |
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Entrez Gene |
80059
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UniGene |
Hs.285782
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RefSeq |
NP_001269853
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HUGO |
HGNC:19411
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OMIM |
610870
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CCDS |
CCDS46346
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HPRD |
11288
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IMGT |
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EMBL |
AC013408
AC013716
AC016758
AC068048
AC068616
AC079117
AC079146
AC079614
AC093650
AL353610
AY182030
AY358324
BC099738
BC110058
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GenPept |
AAH99738
AAI10059
AAO67551
AAQ88690
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